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KMID : 0351619740150010089
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Kyungpook Medical Journal
1974 Volume.15 No. 1 p.89 ~ p.95
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Effects of Ethanol on ATP and Protein Synthesis of Normal and Regenerating Liver in Rats
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Abstract
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Since ethanol administration increases the incorporation of labelled amino acid into liver and serum proi;ein (Lee, H. Y. and Ryoo, H.: Kyurgpook National University Med. J. , 11:89,1970) a~:d liver ATP concentration (French, S. W.: Proc. Soc. Exp. Biol. Yted. 121: 681, 1966), studies were undertaken to evaluate the relations between ATP concentration and protein synthesis in liver of rats after ethanol administration. The rate of protein synthesis was determined by measuring the incorporation rate of L-lysine-1´´C into liver protein. In normal rats ethanol administration caused a significant increase of protein synthesis in liver, but the increase of liver ATP was less significant.
Protein synthesis of liver in rats following the administration of a single large dose o~ ethanol (1. Zml of 50% ethanol per 100g body weight) showed a sii;nificart increase after 4 hours aad maintained the level for 16 hours. Liver ATP concentration in the same rats showed only a transient increase after 8 hours the administration of ethanol.
In the rats of 40 hours posthepatectomy, ethanol oxidation observed from disappearance curve of ethanol in blood after the administration (0.9m1 of 50% ethanol per 100g bady weight) v; as almost recovered to the normal activity.
Regenerating liver of 40 hours posthepatectomy showed a. significant decrease of ATP cor_c~ntration whereas the protein synthesis was so increased.
Even though the ethanol administration increased the protein synthesis and ATP concertrat:on in the regenerating liver, the ATP level was still lower than in normal liver.
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